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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salsman, Tim | CF | Augusta GreenJackets | 22 | 11/04/2003 | Lac-Lapierre | CAN | Left | Left | 6' 1" | 170 lbs | - |
| Samuels, Alex | SP | Free Agent | 24 | 08/12/2001 | Wahiawa | USA | Right | Right | 5' 11" | 185 lbs | - |
| Samuels, Ed | LF | Greenville Drive | 24 | 12/18/2001 | Mobile | USA | Right | Right | 6' 4" | 205 lbs | - |
| Sandoval, Dave | LF | West Virginia Power | 26 | 02/16/2000 | Cambridge | USA | Right | Right | 6' 0" | 205 lbs | - |
| Sandoval, Tony | RP | Free Agent | 23 | 07/07/2002 | Barahona | DOM | Left | Right | 6' 1" | 175 lbs | - |
| Santana, Ron | SP | West Virginia Power | 25 | 05/11/2000 | Fremont | USA | Right | Right | 6' 0" | 190 lbs | - |
| Santorio, Rodolphe | RF | Kannapolis Intimidators | 21 | 10/11/2004 | Los Teques | VEN | Left | Right | 6' 2" | 185 lbs | - |
| Saraiva, Salomão | 2B | Lexington Legends | 23 | 02/15/2003 | Trujillo | VEN | Left | Right | 6' 2" | 195 lbs | - |
| Sarretti, César | C | West Virginia Power | 21 | 06/06/2004 | Maturín | VEN | Right | Right | 6' 4" | 200 lbs | - |
| Savage, Mike | SP | Lakewood BlueClaws | 24 | 10/30/2001 | Sioux Falls | USA | Right | Right | 6' 2" | 200 lbs | - |
| Scharf, Waylon | 2B | Free Agent | 26 | 09/01/1999 | Springfield | USA | Right | Right | 6' 1" | 200 lbs | - |
| Schneider, Chris | 2B | Lakewood BlueClaws | 22 | 08/19/2003 | Houston | USA | Right | Right | 6' 1" | 190 lbs | - |
| Scott, Ed | SP | Free Agent | 26 | 12/19/1999 | Hollister | USA | Left | Left | 6' 0" | 185 lbs | - |
| Scott, Ron | RP | Asheville Tourists | 23 | 10/13/2002 | Chula Vista | USA | Switch | Right | 6' 0" | 185 lbs | - |
| Selem, Mauro | C | Savannah Sand Gnats | 21 | 07/11/2004 | Chichigalpa | NCA | Right | Right | 5' 10" | 185 lbs | - |
| Serra, Xadreque | RF | Lexington Legends | 22 | 11/06/2003 | Vila Velha | BRA | Left | Left | 6' 4" | 190 lbs | - |
| Seymour, Jeff | RP | Kannapolis Intimidators | 22 | 11/16/2003 | Londontowne | USA | Right | Right | 6' 4" | 195 lbs | - |
| Shibutani, Sean | RP | Greenville Drive | 25 | 12/17/2000 | Jersey City | USA | Right | Right | 6' 1" | 195 lbs | - |
| Shoemake, Don | RP | Hagerstown Suns | 21 | 10/24/2004 | Houston | USA | Left | Left | 6' 2" | 185 lbs | - |
| Short, Jimmy | RP | Hagerstown Suns | 22 | 06/24/2003 | Niagara Falls | USA | Left | Left | 6' 3" | 200 lbs | - |
| Simmons, Sammy | CF | Kannapolis Intimidators | 22 | 04/19/2003 | Harrah | USA | Right | Right | 6' 2" | 200 lbs | - |
| Sims, Andy | CF | Hagerstown Suns | 19 | 07/08/2006 | Crest Hill | USA | Right | Right | 6' 6" | 190 lbs | - |
| Sims, Dave | CF | Free Agent | 26 | 03/19/2000 | Marlton | USA | Right | Right | 6' 2" | 200 lbs | - |
| Smith, Greg | SP | Asheville Tourists | 20 | 07/25/2005 | Moreno Valley | USA | Left | Right | 6' 4" | 185 lbs | - |
| Smith, Jim | 2B | West Virginia Power | 25 | 09/20/2000 | North Augusta | USA | Right | Right | 6' 1" | 190 lbs | - |
| Smith, Ken | 2B | Delmarva Shorebirds | 21 | 08/01/2004 | Columbus | USA | Right | Right | 6' 2" | 185 lbs | - |
| Sorensen, Ricky | RP | Savannah Sand Gnats | 24 | 07/06/2001 | Washington | USA | Left | Left | 6' 7" | 205 lbs | - |
| Soto, Jorge | SP | Free Agent | 23 | 02/12/2003 | Bogota | COL | Right | Right | 6' 0" | 185 lbs | - |
| Spence, Chris | C | Free Agent | 25 | 10/21/2000 | Alexandria | USA | Right | Right | 6' 0" | 200 lbs | - |
| Stevens, Jim | C | Delmarva Shorebirds | 22 | 10/30/2003 | Longboat Key | USA | Right | Right | 6' 0" | 200 lbs | - |
| Stevens, Mike | RP | Free Agent | 24 | 06/13/2001 | Butte | USA | Right | Right | 6' 1" | 195 lbs | - |
| Stewart, Bob | RP | Greenville Drive | 22 | 06/25/2003 | New York | USA | Switch | Right | 6' 1" | 195 lbs | - |
| Stroud, Billy | CF | Greensboro Grasshoppers | 22 | 06/10/2003 | Yucaipa | USA | Right | Right | 6' 2" | 185 lbs | - |
| Sutton, Irving | 2B | Free Agent | 27 | 03/15/1999 | Murrieta | USA | Right | Right | 5' 9" | 200 lbs | - |
| Sánchez, Jesús | 3B | Savannah Sand Gnats | 21 | 08/10/2004 | Santiago | DOM | Right | Right | 6' 4" | 205 lbs | - |
| Sánchez, José | CL | Greensboro Grasshoppers | 23 | 01/15/2003 | Cayey | PUR | Right | Right | 6' 0" | 190 lbs | - |
| Sánchez, Rubén | CF | Lexington Legends | 22 | 08/29/2003 | Higüey | DOM | Right | Right | 6' 1" | 185 lbs | - |
