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| Wednesday, November 23rd , 2022 |
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| Pawtucket Red Sox: LF Mikie Mahtook becomes a free-agent. |
| Buffalo Bisons: RP Jairo Diaz becomes a free-agent. |
| Buffalo Bisons: RP Michael Fulmer becomes a free-agent. |
| Columbus Clippers: RP Jeferson Mejia becomes a free-agent. |
| Columbus Clippers: LF Kes Carter becomes a free-agent. |
| Syracuse Chiefs: 3B Jomar Reyes becomes a free-agent. |
| Saturday, November 12th , 2022 |
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| Gwinnett Firebirds: Signed Manager Jason Bourgeois. |
| Durham Bulls: Signed Manager Ron Anderson. |
| Friday, November 4th , 2022 |
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| Durham Bulls: Released C Bert Boreland. |
| Tuesday, November 1st , 2022 |
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| Syracuse Chiefs: SP Tim Lincecum retired from professional baseball. |
| Pawtucket Red Sox: RF Artie Young retired from professional baseball. |
| Buffalo Bisons: SP Kevin Bowling retired from professional baseball. |
| Syracuse Chiefs: 2B Greg Bland retired from professional baseball. |
| Toledo Mud Hens: RP Jeremy Jeffress retired from professional baseball. |
| Toledo Mud Hens: SP Steve Bartlett retired from professional baseball. |
| Buffalo Bisons: CF Pete Mobley retired from professional baseball. |
| Buffalo Bisons: 3B Johnny Muldrow retired from professional baseball. |
| Syracuse Chiefs: C Jeremy Evans retired from professional baseball. |
| Scranton WB RailRiders: 2B Tony Balch retired from professional baseball. |
| Syracuse Chiefs: SS Ted Mills retired from professional baseball. |
| Buffalo Bisons: CF Don Anderson retired from professional baseball. |
| Pawtucket Red Sox: SS Adeiny Hechavarria retired from professional baseball. |
| Toledo Mud Hens: 3B Mark Malave retired from professional baseball. |
| Scranton WB RailRiders: 1B Drew Bridges retired from professional baseball. |
| Buffalo Bisons: SP Curt Caldwell retired from professional baseball. |
| Rochester Red Wings: SP Fernando Romero retired from professional baseball. |
| Lehigh Valley IronPigs: C Rainiero Coa retired from professional baseball. |
| Rochester Red Wings: 3B Porfirio A. Martinez retired from professional baseball. |
| Syracuse Chiefs: 2B José Cruz retired from professional baseball. |
| Syracuse Chiefs: Pitching Coach John Duffy retires. |
| Syracuse Chiefs: Hitting Coach Nelson Santovenia retires. |
| Norfolk Tides: Hitting Coach Valentyn Galvon leaves the team, his contract was not renewed |
| Pawtucket Red Sox: Hitting Coach Brian Turang leaves the team, his contract was not renewed |
| Durham Bulls: Pitching Coach Domingo Beltrán leaves the team, his contract was not renewed |
| Durham Bulls: Manager Denny Hocking leaves the team, his contract was not renewed |
| Gwinnett Firebirds: Manager Ryan Minor leaves the team, his contract was not renewed |
| Gwinnett Firebirds: Hitting Coach Kevin Randel leaves the team, his contract was not renewed |
| Monday, October 31st , 2022 |
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| Durham Bulls: Released 2B Riley Unroe. |
| Friday, September 23rd , 2022 |
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| Indianapolis Arrows: SS Elvis Andrus retired from professional baseball. |
| Columbus Clippers: CL Juan Jaime retired from professional baseball. |
