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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sanchez, Manny | RF | Scranton WB RailRiders | 30 | 10/06/1995 | San Juan de la Maguana | DOM | Right | Right | 6' 2" | 225 lbs | - |
| Santos, Daniel | CF | Lehigh Valley IronPigs | 25 | 04/16/2000 | Eufaula | USA | Right | Right | 6' 3" | 200 lbs | - |
| Savinon, Jose | 2B | Free Agent | 29 | 02/17/1996 | Unknown | DOM | Left | Right | 6' 0" | 195 lbs | - |
| Schmidt, Ezra | SP | Louisville Bats | 29 | 10/12/1996 | Statesville | USA | Left | Left | 6' 4" | 210 lbs | $740,000 |
| Sepulveda, Carlos | 2B | Syracuse Chiefs | 29 | 08/27/1996 | Monclova | MEX | Left | Right | 5' 10" | 175 lbs | $3,318,000 |
| Sheehan, Dan | CF | Louisville Bats | 26 | 09/25/1999 | Parsippany-Troy Hills Township | USA | Left | Right | 6' 4" | 205 lbs | $740,000 |
| Sheffield, Justus | SP | Free Agent | 29 | 05/13/1996 | Tullahoma | USA | Left | Left | 5' 10" | 200 lbs | - |
| Shiplack, Emmitt | 2B | Norfolk Tides | 24 | 12/14/2000 | Markham | CAN | Switch | Right | 6' 3" | 205 lbs | - |
| Silva, Orlando | LF | Charlotte Knights | 24 | 05/01/2001 | Villa Altagracia | DOM | Left | Right | 6' 1" | 180 lbs | $740,000 |
| Silva, Álex | 1B | Pawtucket Red Sox | 26 | 07/23/1999 | Ponce | PUR | Left | Left | 6' 0" | 200 lbs | - |
| Simpson, Jared | 3B | Rochester Red Wings | 25 | 09/18/2000 | Lebanon | USA | Right | Right | 6' 3" | 200 lbs | $740,000 |
| Sisco, Chance | C | Free Agent | 30 | 02/24/1995 | Corona | USA | Left | Right | 6' 0" | 200 lbs | - |
| Smart, Jarred | SP | Toledo Mud Hens | 29 | 11/23/1995 | Fayetteville | USA | Left | Left | 6' 4" | 210 lbs | - |
| Smiley, Dave | SP | Charlotte Knights | 27 | 03/17/1998 | Inglewood | USA | Right | Right | 6' 0" | 185 lbs | $1,100,000 |
| Smith, Jerry | CF | Toledo Mud Hens | 24 | 05/03/2001 | Leawood | USA | Left | Left | 6' 2" | 190 lbs | - |
| Smith, Lou | 2B | Pawtucket Red Sox | 28 | 07/15/1997 | Chicago | USA | Right | Right | 6' 2" | 200 lbs | - |
| Smith, Mallex | LF | Columbus Clippers | 32 | 05/06/1993 | Tallahassee | USA | Left | Right | 5' 9" | 200 lbs | - |
| Smith, Scot | 3B | Norfolk Tides | 26 | 04/13/1999 | North Chicago | USA | Left | Right | 6' 2" | 205 lbs | - |
| Smith, Tony | RF | Charlotte Knights | 24 | 10/06/2001 | Boise | USA | Left | Left | 6' 1" | 195 lbs | - |
| Sosa, Edmundo | 2B | Lehigh Valley IronPigs | 29 | 03/06/1996 | Panama | PAN | Right | Right | 5' 11" | 190 lbs | - |
| Sosa, José | CF | Rochester Red Wings | 24 | 02/21/2001 | Cúa | VEN | Left | Left | 6' 2" | 190 lbs | - |
| Sperring, Mike | CF | Columbus Clippers | 27 | 10/07/1998 | East Haven | USA | Right | Left | 6' 0" | 185 lbs | - |
| Springer, George | RF | Free Agent | 36 | 09/19/1989 | New Britain | USA | Right | Right | 6' 3" | 205 lbs | - |
| Stanford, Oscar | RP | Indianapolis Arrows | 24 | 01/29/2001 | Columbus | USA | Right | Right | 6' 4" | 200 lbs | $740,000 |
| Stanley, Steve | SS | Lehigh Valley IronPigs | 32 | 09/22/1993 | Binghamton | USA | Switch | Right | 6' 1" | 190 lbs | $740,000 |
| Starks, Mike | CF | Free Agent | 27 | 11/23/1997 | Donalsonville | USA | Right | Right | 6' 3" | 200 lbs | - |
| Stevens, Thom | RP | Syracuse Chiefs | 25 | 08/30/2000 | Philadelphia | USA | Right | Right | 6' 0" | 185 lbs | $740,000 |
| Stewart, Ron | SP | Charlotte Knights | 24 | 01/28/2001 | Ewa Beach | USA | Switch | Right | 6' 7" | 210 lbs | - |
| Stuart, Champ | LF | Lehigh Valley IronPigs | 33 | 10/11/1992 | Nassau | BAH | Right | Right | 6' 0" | 205 lbs | - |
| Suri, Wasim | RP | Syracuse Chiefs | 25 | 08/27/2000 | Long Beach | USA | Left | Left | 6' 2" | 195 lbs | - |
| Sutton, Vic | LF | Norfolk Tides | 26 | 06/09/1999 | Thornton | USA | Right | Right | 6' 6" | 210 lbs | $740,000 |
| Sánchez, Augusto | RP | Charlotte Knights | 24 | 09/08/2001 | Araure | VEN | Left | Left | 6' 4" | 195 lbs | - |
